Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC042
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-30 13:39
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 New patient

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 32 individuals with a value less than 0.64 were subsequently diagnosed with PD. That is, 76.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.64 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 15, 'TN': 12, 'TP': 27, 'FP': 18}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 9, 'TN': 10, 'TP': 33, 'FP': 20}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 24, 'TN': 17, 'TP': 18, 'FP': 13}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 10.124
timePerCircleCoV 0.269812
timePerCircleSlope -0.0661614
meanError 1.38266
tremorFreq 6.64062
tremorRelPower 28.1944
tremorGyroAmpMean 0.0348509
tremorGyroAmpSlope 0.00144449
tremorGyroAmpCoV 0.349985
tremorCoordAmpMean 0.0597916
tremorCoordAmpSlope 0.00732481
tremorCoordAmpCoV 0.403469
tremorAccAmpMean 0.0507261
tremorAccAmpSlope 0.00585326
tremorAccAmpCoV 0.403456
tremorPcRelVar 0.575532
tremorPcX 0.881234
tremorPcY 0.47268

Circle Segment 1

Duration 16.48 s, Accuracy Estimate 0.866 (lower is better)

Circle Segment 2

Duration 13.04 s, Accuracy Estimate 1.168 (lower is better)

Circle Segment 3

Duration 10.12 s, Accuracy Estimate 1.234 (lower is better)

Circle Segment 4

Duration 10.56 s, Accuracy Estimate 1.077 (lower is better)

Circle Segment 5

Duration 7.84 s, Accuracy Estimate 1.3 (lower is better)

Circle Segment 6

Duration 8.28 s, Accuracy Estimate 1.136 (lower is better)

Circle Segment 7

Duration 7.84 s, Accuracy Estimate 1.755 (lower is better)

Circle Segment 8

Duration 9.64 s, Accuracy Estimate 1.383 (lower is better)

Circle Segment 9

Duration 8.88 s, Accuracy Estimate 1.273 (lower is better)

Circle Segment 10

Duration 8.56 s, Accuracy Estimate 2.634 (lower is better)

Spiral

numSpirals 7
timePerSpiralMean 35.8286
timePerSpiralCoV 0.116272
timePerSpiralSlope 0.028429
meanError 1.44007
tremorFreq 6.44531
tremorRelPower 23.4531
tremorGyroAmpMean 0.0368416
tremorGyroAmpSlope -0.00204298
tremorGyroAmpCoV 0.428272
tremorCoordAmpMean 0.0599312
tremorCoordAmpSlope -0.000673592
tremorCoordAmpCoV 0.413515
tremorAccAmpMean 0.0548231
tremorAccAmpSlope -0.000744697
tremorAccAmpCoV 0.382307
tremorPcRelVar 0.642075
tremorPcX 0.0158667
tremorPcY 0.999874

Spiral Segment 1

Duration 38.28 s, Accuracy Estimate 1.278 (lower is better)

Spiral Segment 2

Duration 30.68 s, Accuracy Estimate 1.313 (lower is better)

Spiral Segment 3

Duration 29.88 s, Accuracy Estimate 1.541 (lower is better)

Spiral Segment 4

Duration 37.04 s, Accuracy Estimate 1.677 (lower is better)

Spiral Segment 5

Duration 36.84 s, Accuracy Estimate 1.443 (lower is better)

Spiral Segment 6

Duration 36.48 s, Accuracy Estimate 1.611 (lower is better)

Spiral Segment 7

Duration 41.6 s, Accuracy Estimate 1.218 (lower is better)

Elel

eDurationMean 0.604744
eDurationStd 0.110679
eDurationStdnorm 0.183019
eDurationMedian 0.605
eDurationQuartdelta 0.15375
eDurationQuartdeltanorm 0.254132
eDurationKurt 2.94692
eDurationTrenddiff -0.15
eDurationTrendratio 0.777778
eWidthMean 5.649
eWidthStd 1.41243
eWidthStdnorm 0.250032
eWidthMedian 5.733
eWidthQuartdelta 2.2815
eWidthQuartdeltanorm 0.397959
eWidthKurt 2.28894
eWidthTrenddiff 1.989
eWidthTrendratio 1.47222
eHeightMean 6.663
eHeightStd 1.15167
eHeightStdnorm 0.172846
eHeightMedian 6.435
eHeightQuartdelta 1.053
eHeightQuartdeltanorm 0.163636
eHeightKurt 10.8133
eHeightTrenddiff 0
eHeightTrendratio 1
eAspectMean 0.850614
eAspectStd 0.179205
eAspectStdnorm 0.210677
eAspectMedian 0.861538
eAspectQuartdelta 0.259575
eAspectQuartdeltanorm 0.301292
eAspectKurt 2.11497
eAspectTrenddiff 0.237681
eAspectTrendratio 1.34167
eSlantMean 0.23942
eSlantStd 0.239578
eSlantStdnorm 1.00066
eSlantMedian 0.214286
eSlantQuartdelta 0.440668
eSlantQuartdeltanorm 2.05645
eSlantKurt 1.85153
eSlantTrenddiff 0.355094
eRtopMean 0.721035
eRtopStd 0.0934503
eRtopStdnorm 0.129606
eRtopMedian 0.727273
eRtopQuartdelta 0.172519
eRtopQuartdeltanorm 0.237213
eRtopKurt 1.95407
eRtopTrenddiff 0.00659134
eRbotMean 0.465655
eRbotStd 0.213845
eRbotStdnorm 0.459235
eRbotMedian 0.444444
eRbotQuartdelta 0.318282
eRbotQuartdeltanorm 0.716134
eRbotKurt 2.05268
eRbotTrenddiff -0.28647
eRrightMean 0.84172
eRrightStd 0.0577528
eRrightStdnorm 0.0686128
eRrightMedian 0.843137
eRrightQuartdelta 0.0846154
eRrightQuartdeltanorm 0.100358
eRrightKurt 2.51776
eRrightTrenddiff -0.0294604
eRleftMean 0.225254
eRleftStd 0.0806632
eRleftStdnorm 0.358098
eRleftMedian 0.22807
eRleftQuartdelta 0.11787
eRleftQuartdeltanorm 0.516816
eRleftKurt 2.38498
eRleftTrenddiff -0.0941558
lDurationMean 0.768158
lDurationStd 0.14443
lDurationStdnorm 0.188021
lDurationMedian 0.75
lDurationQuartdelta 0.225
lDurationQuartdeltanorm 0.3
lDurationKurt 2.77794
lDurationTrenddiff -0.205
lDurationTrendratio 0.767045
lWidthMean 8.33779
lWidthStd 1.96395
lWidthStdnorm 0.235548
lWidthMedian 8.307
lWidthQuartdelta 2.457
lWidthQuartdeltanorm 0.295775
lWidthKurt 3.68768
lWidthTrenddiff 2.223
lWidthTrendratio 1.29688
lHeightMean 13.3072
lHeightStd 1.84085
lHeightStdnorm 0.138335
lHeightMedian 13.0455
lHeightQuartdelta 1.755
lHeightQuartdeltanorm 0.134529
lHeightKurt 5.59855
lHeightTrenddiff -0.117
lHeightTrendratio 0.991071
lAspectMean 0.63249
lAspectStd 0.146951
lAspectStdnorm 0.232337
lAspectMedian 0.642318
lAspectQuartdelta 0.209533
lAspectQuartdeltanorm 0.326214
lAspectKurt 2.27186
lAspectTrenddiff 0.207849
lAspectTrendratio 1.39365
lSlantMean 0.38456
lSlantStd 0.180483
lSlantStdnorm 0.469324
lSlantMedian 0.401754
lSlantQuartdelta 0.252294
lSlantQuartdeltanorm 0.62798
lSlantKurt 2.54427
lSlantTrenddiff 0.188034
lRtopMean 0.940927
lRtopStd 0.0359595
lRtopStdnorm 0.0382171
lRtopMedian 0.948409
lRtopQuartdelta 0.054204
lRtopQuartdeltanorm 0.0571526
lRtopKurt 2.34318
lRtopTrenddiff -0.0104364
lRbotMean 0.360111
lRbotStd 0.18547
lRbotStdnorm 0.515035
lRbotMedian 0.326658
lRbotQuartdelta 0.199226
lRbotQuartdeltanorm 0.60989
lRbotKurt 3.45614
lRbotTrenddiff -0.144536
lRrightMean 0.953584
lRrightStd 0.0336265
lRrightStdnorm 0.0352633
lRrightMedian 0.959339
lRrightQuartdelta 0.043812
lRrightQuartdeltanorm 0.045669
lRrightKurt 3.64682
lRrightTrenddiff -0.0073092
lRleftMean 0.150133
lRleftStd 0.0669912
lRleftStdnorm 0.446212
lRleftMedian 0.133631
lRleftQuartdelta 0.0922574
lRleftQuartdeltanorm 0.69039
lRleftKurt 3.18709
lRleftTrenddiff -0.0555556

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.864592
sumTouchScores 22.4794
meanMovementTime 0.72
numTouches 26
undershootPercentage 0
overshootPercentage 19.2308

FITTS Long Modified

meanTouchScore 0.867977
sumTouchScores 17.3595
meanMovementTime 0.907895
numTouches 20
undershootPercentage 0
overshootPercentage 30

ZigZag

numZigzags 5
timePerZigzagMean 28.84
timePerZigzagCoV 0.199337
timePerZigzagSlope -0.116505
meanError 2.71761
tremorFreq 6.64062
tremorRelPower 28.5724
tremorGyroAmpMean 0.0460886
tremorGyroAmpSlope 0.00256415
tremorGyroAmpCoV 0.389222
tremorCoordAmpMean 0.115866
tremorCoordAmpSlope 0.00120795
tremorCoordAmpCoV 0.757142
tremorAccAmpMean 0.0622933
tremorAccAmpSlope 0.00191529
tremorAccAmpCoV 0.383315
tremorPcRelVar 0.830409
tremorPcX -0.0446612
tremorPcY 0.999002

ZigZag Segment 1

Duration 36.52 s, Accuracy Estimate 2.411 (lower is better)

ZigZag Segment 2

Duration 33.48 s, Accuracy Estimate 2.643 (lower is better)

ZigZag Segment 3

Duration 25.16 s, Accuracy Estimate 2.624 (lower is better)

ZigZag Segment 4

Duration 25.16 s, Accuracy Estimate 2.699 (lower is better)

ZigZag Segment 5

Duration 23.88 s, Accuracy Estimate 3.212 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 15.68
timePerZigzagCoV 0.214377
timePerZigzagSlope -0.124745
zigzagHeightMean 67.7496
zigzagHeightCoV 0.0357423
zigzagHeightSlope 0.0188077
meanError 0.0401294
tremorFreq 6.15234
tremorRelPower 29.8968
tremorGyroAmpMean 0.0559737
tremorGyroAmpSlope 0.000115961
tremorGyroAmpCoV 0.346379
tremorCoordAmpMean 0.211494
tremorCoordAmpSlope 0.014184
tremorCoordAmpCoV 1.01988
tremorAccAmpMean 0.100933
tremorAccAmpSlope 6.74952e-05
tremorAccAmpCoV 0.168611
tremorPcRelVar 0.847544
tremorPcX -0.259514
tremorPcY -0.965739

ZigZag Offset Segment 1

Duration 21.0 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 2

Duration 16.88 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 3

Duration 13.8 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 4

Duration 14.12 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 5

Duration 12.6 s, Accuracy Estimate 0.058 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.64}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.3608902813873913}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8688668977534137}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.357491546774065}